Year: 2020 | Month: October | Volume 10 | Issue 5
Dose Sparing Effects of Butorphanol and Diazepam or Midazolam Premedication on Propofol Total Intravenous Anaesthesia in Dogs
Surbhi K. Tyagi
Manisha P. Pratap
D.N. Suthar
R.H. Bhatt
S.K. Jhala
V.S. Dabas
Divya Chaudhari
DOI:10.30954/2277-940X.05.2020.15
Abstract:
The objective of the study was to evaluate & compare the dose sparing effect of atropine-butorphanol-diazepam (A-B-D) and atropine-butorphanol-midazolam (A-B-M) combination as basal anaesthesia on induction and maintenance dose of propofol used as Total intravenous anaesthesia (TIVA) in dogs. Thirteen dogs were randomly divided into group I (n=7) & group II (n=6), wherein atropine, butorphanol, diazepam/midazolam were given as preanaesthetic drugs, while, induction and maintenance of anaesthesia was done with propofol. Systolic blood pressure, diastolic blood pressure, mean arterial pressure and peripheral capillary oxygen saturation (SpO2) were recorded after induction of anaesthesia, at regular 15 minute intervals, up to 45 minutes. The physiological parameters were recorded before giving any drug and thereafter at regular 15 minute interval post induction. In midazolam-butorphanol group, the induction and maintenance dose of propofol was non-significantly higher than in diazepam-butorphanol group. Both diazepam-butophanol and midazolam-butorphanol have dose sparing effect on induction and maintenance dose of propofol, however, diazepam-butorphanol combination is slightly better than midazolam-butorphanol combination.
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